His main research interest focuses on polymeric biomaterials and biological interface. Based on the biomimic strategy, several supramolecular self-assemble methods were explored to develop biocompatible and biofunctional materials. Electrostatic self –assembly” method, which based on the alternating physisorption of oppositely charged polyelectrolytes, was explored to develop several functional multilayer coating onto biomaterial to represent the desirable properties, such as anti-coagulation, promote cytocompatibility and control release of DNA. In following the biological perspective of glycocalyx, the poly(ethylene oxide) comb-like copolymers were explored to engineer glycocalyx-mimic surfaces, which reduce the non-specific interaction and end-tethered ligand to trigger biomolecules self-assemble. Get inspiration of the cell membrane structure, a kind of cell membrane biomimetic micelles were developed via supramolecular aggregation of a biomimetic amphiphilies. The biomimetic nano-carriers show low toxicity and high cell uptake ratio, which might be suitable as a carrier vehicle for delivering bioactive agents.
Tingting Chen, Hadi Bakhshi, Li Liu, Jian Ji*, and Seema Agarwal*, Combining 3D Printing with Electrospinning for Rapid Response and Enhanced Designability of Hydrogel Actuators, Advanced Functional Materials, 2018, 28, 1800514.
Haijie Han, Daniel Valdeper, Qiao Jin*, Bin Yang, Zuhong Li, Yulian Wu, Beatriz Pelaz, Wolfgang J. Parak, Jian Ji*, Dual Enzymatic Reaction-Assisted Gemcitabine Delivery Systems for Programmed Pancreatic Cancer Therapy, ACS Nano, 2017, 11, 1281−1291.
Dengfeng Hu, Huan Li, Bailiang Wang, Zi Ye, Wenxi Lei, Fan Jia, Qiao Jin, Ke-Feng Ren, and Jian Ji*, Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm, ACS Nano, 2017, 11, 9330−9339.
Xiangsheng Liu, Yangjun Chen, Huan Li, Nan Huang, Qiao Jin, Kefeng Ren, Jian Ji*, Enhanced Retention and Cellular Uptake of Nanoparticles in Tumors by Controlling Their Aggregation Behavior, ACS Nano, 2013,7, 6244-6257.
Xiangsheng Liu , Jieming Cao , Huan Li , Jianyu Li , Qiao Jin , Kefeng Ren , and Jian Ji *, Mussel-Inspired Polydopamine: A Biocompatible and Ultrastable Coating for Nanoparticles in Vivo, ACS Nano, 2013, 7 (10), 9384–9395.
Tingting Chen, Huan Li, Zuhong Li, Qiao Jin*, Jian Ji*, A ‘‘writing’’ strategy for shape transition with infinitely adjustable shaping sequences and in situ tunable 3D structures, Materials Horizons, 2016,3,581-587.
Xiachao Chen, Kefeng Ren,* Jiahui Zhang, Dandan Li, Emily Zhao, Zhong Jonathon Zhao, Zhikang Xu, Jian Ji*. Humidity-Triggered Self-Healing of Microporous Polyelectrolyte Multilayer Coatings for Hydrophobic Drug Delivery. Advanced Functional Materials 2015, 25, 7470-7477.
He Zhang, Kefeng Ren*, Hao Chang, Jinlei Wang, Jian Ji*, Surface-mediated transfection of a pDNA vector encoding short hairpin RNA to downregulate TGF-b1 expression for the prevention of in-stent restenosis, Biomaterials, 2017, 116, 95-105.
Jinlei Wang#; Bochao Li#; Zijun Li; Kefeng Ren*; Liejiang Jin; Shimiao Zhang; Hao Chang; Yixin Sun; Jian Ji*, Electropolymerization of dopamine for surface modification of complex-shaped cardiovascular stents, Biomaterials 2014, 35, 7679-7689.
Hao Chang, Kefeng Ren*, Jin-lei Wang, He Zhang, Bailiang Wang, Shan-mei Zheng, Yuanyuan Zhou, Jian Ji*, Surface-mediated functional gene delivery: An effective strategy for enhancing competitiveness of endothelial cells over smooth muscle cells, Biomaterials, 2013, 34, 3345-3354.
Yu Wei, Ying Ji, Lin-Lin Xiao, Quakui Lin, Jian-ping Xu, Kefeng Ren, Jian Ji*, Surface engineering of cardiovascular stent with endothelial cell selectivity for in vivo re-endothelialisation, Biomaterials 2013,34, 2588-2599.
Xiangsheng Liu, Nan Huang, Haibo Wang, Huan Li, Qiao Jin, Jian Ji*，The effect of ligand composition on the in vivo fate of multidentate poly(ethylene glycol) modified gold nanoparticles, Biomaterials 2013,34, 8370-8381.
Zuhong Li, Haibo Wang, Yangjun Chen, Yin Wang, Huan Li, Haijie Han, Tingting Chen, Qiao Jin,* Jian Ji*, pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistancein Cancer Treatment, Small, 2016, 12, 20, 2731–2740.
Haijie Han, Qiao Jin,* Haibo Wang, Wenzhuo Teng, Jina Wu, Hongxin Tong, Tingting Chen, Jian Ji*, Intracellular Dual Fluorescent Lightup Bioprobes for Image-Guided Photodynamic Cancer Therapy, Small, 2016, 12(28), 3870–3878.
Hongxin Tong, Yangjun Chen, Zuhong Li, Huan Li, Tingting Chen, Qiao Jin*, Jian Ji*, Glutathione Activatable Photosensitizer-Conjugated Pseudopolyrotaxane Nanocarriers for Photodynamic Theranostics, Small, 12(45), 6223-6232.
Xiangsheng Liu; Huan Li; Qiao Jin; Jian Ji*, Surface tailoring of nanoparticles via mixed-charge monolayers and their biomedical applications, Small 2014, 10, 4230-4242.
Xiaoli Fan, Mihu, Zhihui Qin, Jing Wang, Xiachao Chen, Wenxi Lei, Wanying Ye, Qiao Jin, Kefeng Ren* and Jian Ji*, Bactericidal and Hemocompatible Coating via the Mixed-Charged Copolymer, ACS Applied Materials & Interfaces, 2018, 10(12), 10428-10436.
Fan Jia, Yongyan Deng and Jian Ji*, The renaissance of nitric oxide: from improvement of stability to enhancement of endocytosis, Materials Chemistry Frontiers, 2018, 2, 830-834.
Jina Wu, Haijie Han, Qiao Jin*, Zuhong Li, Huan Li, Jian Ji*, Design and proof of programmed 5-aminolevulinic acid prodrug nanocarriers for targeted photodynamic cancer therapy, ACS Applied Materials & Interfaces, 2017, 9 (17), 14596–14605.
Xiachao Chen, Kefeng Ren*, Wenxi Lei, Jiahui Zhang, M. Cristina L. Martins, Mário A. Barbosa, Jian Ji*, Self-Healing Spongy Coating for Drug “Cocktail” Delivery, ACS Applied Materials & Interfaces, 2016, 8, 4309.
Yangjun Chen#, Zuhong Li#, Haibo Wang, Yin Wang, Haijie Han, Qiao Jin,* Jian Ji*, IR-780 Loaded Phospholipid Mimicking Homopolymeric Micelles for Near-IR Imaging and Photothermal Therapy of Pancreatic Cancer, ACS Applied Materials & Interfaces, 2016, 8, 6852.
Hao Chang, Mi Hu, He Zhang, Kefeng Ren,* Bochao Li, Huan Li, Limei Wang, Wenxi Lei, Jian Ji*，Improved Endothelial Function of Endothelial Cell Monolayer on the Soft Polyelectrolyte Multilayer Film with Matrix-Bound Vascular Endothelial Growth Factor，ACS Applied Materials & Interfaces, 2016, 8, 14357.
Yangjun Chen, Haijie Han, Hongxin Tong, Tingting Chen, Haibo Wang, Jian Ji,* Qiao Jin*, Zwitterionic Phosphorylcholine−TPE Conjugate for pH-Responsive Drug Delivery and AIE Active Imaging, ACS Applied Materials & Interfaces, 2016, 8, 21185.
Xiangsheng Liu; Nan Huang; Huan Li; Haibo Wang; Qiao Jin; Jian Ji*, Multidentate polyethylene glycol modified gold nanorods for in vivo near-infrared photothermal cancer therapy. ACS Applied Materials & Interfaces 2014, 6, 5657-5668.
Huan Li#; Xiangsheng Liu#; Nan Huang; Kefeng Ren; Qiao Jin; Jian Ji*, “Mixed-charge Self-Assembled Monolayers” as a facile method to design pH-induced aggregation of large gold nanoparticles for near-infrared photothermal cancer therapy, ACS Applied Materials & Interfaces 2014, 6, 18930.
Bailiang Wang, Kefeng Ren*, Jinlei Wang, Hao Chang, Jian Ji*, Construction of Degradable Multilayer Films for Enhanced Antibacterial Properties, ACS Applied Materials & Interfaces,2013,5, 4136-4143.
Yixin Sun, Kefeng Ren,* Jinlei Wang, Guoxun Chang, and Jian Ji*, Electrochemically Controlled Stiffness of Multilayers for Manipulation of Cell Adhesion, ACS Applied Materials & Interfaces, 2013, 29,11163-11168.
