Specialist-Zhejiang University Eye Hospital

Xu Jia M.D., Ph. D.

Academic Rank:Associate Chief Physician

Clinical / Research Interests

Congenital cataract related genes and their pathogenesis; folding and misfolding of crystallin.

Publications

Xu J, Zhao WJ, Chen XJ, Yao K, Yan YB. Introduction of an extra tryptophan fluorophore by cataract-associating mutations destabilizes βB2-crystallin and promotes aggregation. Biochem Biophys Res Commun. 2018 Oct 12;504(4):851-856.

Zhao WJ, Xu J, Chen XJ, Liu HH, Yao K, Yan YB. Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding. Int J Biol Macromol. 2017 Oct;103:764-770.

Zheng XY, Xu J, Li W, Li SS, Shi CP, Zhao ZY, Mao JH, Chen X. Frosted Branch Angiitis in Pediatric Dyskeratosis Congenita: A Case Report. Medicine (Baltimore). 2016 Mar;95(12):e3106.

Chen PQ, Han XM, Zhu YN, Xu J. Comparison of the anti-inflammatory effects of fluorometholone 0.1% combined with levofloxacin 0.5% and tobramycin/dexamethasone eye drops after cataract surgery. Int J Ophthalmol. 2016 Nov 18;9(11):1619-1623.

Xu J, Wang S, Zhao WJ, Xi YB, Yan YB, Yao K. The congenital cataract-linked A2V mutation impairs tetramer formation and promotes aggregation of βB2-crystallin. PLoS One. 2012;7(12):e51200.

Current Program

The importance of conserved tryptophans at βB2-crystallin stability and their photoprotective mechanism. Funding Source: National Natural Science Foundation of China.